Mechanisms of Human Disease
1. You are a pathologist looking under the microscope at liver tissue from a 37-year-old woman obtained at biopsy. The only history the patient’s interest wrote done was “past IV drug use.” You see lymphocytic portal inflammation and portal fibrosis. What are the two most likely diagnoses?
2. Multiple choice.
Based on modes of transmission, which of the following is true?
A. Hepatitis B and hepatitis C are most similar
B. Hepatitis A and hepatitis B are most similar
C. Hepatitis D and hepatitis E are most similar
D. Hepatitis E and hepatitis B are most similar
E. Hepatitis C and hepatitis A are most similar

Which one of these viruses cannot cause chronic hepatitis?
A. Hepatitis A virus
B. Hepatitis D virus concurrent with hepatitis B virus infection
C. Hepatitis C virus
D. Hepatitis B virus
E. None of the above

An isolated elevation in the serum unconjugated (indirect) bilirubin concentration is consistent with which of the following?
A. Primary biliary cirrhosis
B. Acute viral hepatitis
C. Alcoholic hepatitis
D. Dubin-Johnson syndrome
E. Hemolysis

Some people flush when they drink alcohol because of:
A. An allergic reaction to ethanol
B. Deficiency of alcohol dehydrogenase activity
C. Deficiency of aldehyde dehydrogenase activity
D. A relatively common cytochrome P450 gene polymorphism
E. An allergic reaction to acetaldehyde

3. What do you consider an unmet medical need in the area of liver diseases and if you had $50,000,000, how would you address it?

Mechanisms of Human Disease 1. You are a pathologist looking unde...